Enteroviral Infections as a Trigger for Type 1 Diabetes
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چکیده
منابع مشابه
Viral Trigger for Type 1 Diabetes
The most popular hypothesis circulating within and beyond the scientific community is that viral infections enhance or elicit autoimmune disorders such as type 1 diabetes. Indeed, viruses can injure -cells and have been isolated in pancreatic tissues from diabetic patients. However, accumulating evidence suggests that the opposite scenario, which is prevention or amelioration of type 1 diabetes...
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Type 1 diabetes (T1D) is the result of a selective autoimmune destruction of pancreatic islet b-cells, occurring in genetically predisposed subjects, possibly triggered or accelerated by environmental agents (1). Both innate (2) and adaptive (3) immune responses are involved in islet inflammation in T1D. The role of environmental factors has become increasingly relevant, as indicated by the mar...
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Enteroviruses have been reported to be a potential trigger of the development of type 1 diabetes by inducing b-cell autoantibodies and by directly destroying b-cells (1). Although the precise underlying mechanisms for enterovirusmediated development of diabetes remain unknown, the systematic review andmetaanalysis of observational molecular studies demonstrates a clinically significant associat...
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Type 1 diabetes is an autoimmune disease characterized by the destruction of pancreatic b-cells and an absolute deficiency of insulin. Patients with type 1 diabetes are insulin dependent for life and require multiple daily insulin injections or the use of an insulin pump. It has been considered that b-cell dysfunction and death in type 1 diabetes results from a combination of inflammation, auto...
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Type 1 diabetes mellitus (T1DM) is a multifactorial autoimmune disease in which the insulin producing beta cell population is destroyed by the infiltrated T lymphocytes. Even though the exact cause of T1DM is yet to be ascertained, varying degree of genetic susceptibility and environmental factors have been linked to the disease progress and outcome. Mycobacterium avium subsp. paratuberculosis ...
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ژورنال
عنوان ژورنال: Current Diabetes Reports
سال: 2018
ISSN: 1534-4827,1539-0829
DOI: 10.1007/s11892-018-1077-2